Chemical Biology and Synthetic Tool Development
The research in Mads Hartvig Clausen’s group focuses on chemical biology, using synthetic chemistry to develop tool compounds that address key biological questions. This overall research theme manifests in several focus areas, including synthetic methodology, medicinal chemistry, and molecular design. The aim here is to create small-molecule libraries, prodrugs, biologically active compounds, drug delivery strategies, vaccine development, and studies of complex biomolecules such as plant cell wall polysaccharides. We are part of the Chemical Biology unit of Organic Chemistry.
Research
A further focus is the development of prodrugs activated by reactive oxygen species (ROS) for targeted treatment of inflammatory diseases. Furthermore, in combining synthetic design with biological evaluation, we contribute to carbohydrate-based vaccine development.