Nucleic Acid Chemistry and Bioconjugation
Research in the Kira Astakhova Group focuses on the synthesis and study of nucleic acid analogues. We combine rational design, innovative synthetic strategies, and functional assays to explore the properties of functionalized nucleic acids and their conjugates with peptides and polymers. By integrating chemical synthesis with molecular and computational approaches, we aim to develop tools for both fundamental understanding and therapeutic applications. We adhere to the Chemical Biology unit of Organic Chemistry.
Research
Our activities are centered on creating highly informative analytical platforms for nucleic acids. Traditional approaches either rely on technically demanding biological analyses or on amplification-based assays. We seek to integrate these strategies into single, reliable platforms that provide detailed molecular insights.
A major focus is the development of novel bioconjugates and drug formulations to enable efficient delivery of gene therapeutics to target cells. To achieve this, we actively combine computational chemistry, organic synthesis, and molecular biology, designing nucleic acid analogues and their peptide or polymer conjugates for optimized function and delivery. Across all projects, we emphasize the interplay between chemical design, molecular function, and therapeutic potential.
Contact
Kira Gerber Astakhova Associate Professor Mobile: +4593513552 kiraas@kemi.dtu.dk