Publications

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters

Depta, Laura ; Bryce-Rogers, Hogan P. ; Dekker, Nienke J. ; Bønke, Anna Wiehl ; Camporese, Nicolò ; Qian, Mingxing ; Xu, Yuanjian ; Covey, Douglas F. ; Laraia, Luca
in: Journal of Lipid Research, vol: 66, issue: 2

Type: Journal article (Peer reviewed)

Status: Published | Year: 2025 | DOI: https://doi.org/10.1016/j.jlr.2024.100738

Identification of a Privileged Scaffold for Inhibition of Sterol Transport Proteins through the Synthesis and Ring Distortion of Diverse, Pseudo-Natural Products

Bro, Frederik Simonsen ; Depta, Laura ; Dekker, Nienke J. ; Bryce-Rogers, Hogan P. ; Madsen, Maria Lillevang ; Præstegaard, Kaia Fiil ; Petersson, Tino ; Whitmarsh-Everiss, Thomas ; Kubus, Mariusz ; Laraia, Luca
in: ACS Central Science, vol: 11, issue: 1, pages: 136-146

Type: Journal article (Peer reviewed)

Status: Published | Year: 2025 | DOI: https://doi.org/10.1021/acscentsci.4c01657

Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation

He, Nianzhe ; Depta, Laura ; Rossetti, Cecilia ; Caramelle, Lucie ; Cigler, Marko ; Bryce-Rogers, Hogan P. ; Michon, Marine ; Rafn Dan, Oliver ; Hoock, Joseph ; Barbier, Julien ; Gillet, Daniel ; Forrester, Alison ; Winter, Georg E. ; Laraia, Luca
in: Nature Chemical Biology

Type: Journal article (Peer reviewed)

Status: Accepted/In press | Year: 2025 | DOI: https://doi.org/10.1038/s41589-024-01653-x

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP

Cigler, Marko ; Imrichova, Hana ; Frommelt, Fabian ; Caramelle, Lucie ; Depta, Laura ; Rukavina, Andrea ; Kagiou, Chrysanthi ; Hannich, J. Thomas ; Mayor-Ruiz, Cristina ; Superti-Furga, Giulio ; Sievers, Sonja ; Forrester, Alison ; Laraia, Luca ; Waldmann, Herbert ; Winter, Georg E.
in: Nature Chemical Biology, vol: 21, pages: 193–202

Type: Journal article (Peer reviewed)

Status: Published | Year: 2025 | DOI: https://doi.org/10.1038/s41589-024-01614-4

Unifying principles for the design and evaluation of natural product-inspired compound collections

Bro, Frederik Simonsen ; Laraia, Luca
in: Chemical Science, vol: 16, issue: 7, pages: 2961-2979

Type: Review (Peer reviewed)

Status: Published | Year: 2025 | DOI: https://doi.org/10.1039/d4sc08017c

Fluorescent probes and degraders of the sterol transport protein Aster-A

He, Nianzhe ; Depta, Laura ; Sievers, Sonja ; Laraia, Luca
in: Bioorganic and Medicinal Chemistry, vol: 103

Type: Journal article (Peer reviewed)

Status: Published | Year: 2024 | DOI: https://doi.org/10.1016/j.bmc.2024.117673

Sphingomyelin complexed cholesterol controls Lymphocyte function-associated antigen-1 mediated effector T cell function

Patommel, K. A. ; Marti i Lindez, A. A. ; Jaenicke, J. ; Verma, S. ; Edwards-Hicks, J. ; Hess, C. ; Laraia, L. ; Wilson, S. ; Donde, M. ; Lötscher, J. ; Booty, L. M.
in: Swiss Medical Weekly, vol: 154, issue: P11, pages: 16S-16S
Presented at: SSAI Annual Congress 2024

Type: Conference abstract in journal (Peer reviewed)

Status: Published | Year: 2024

Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library

Yao, Ruwei ; Jensen, Anders A. ; Bryce-Rogers, Hogan P. ; Schultz-Knudsen, Katrine ; Zhou, Libin ; Hovendal, Nicklas P. ; Pedersen, Henrik ; Kubus, Mariusz ; Ulven, Trond ; Laraia, Luca
in: Journal of Medicinal Chemistry, vol: 66, issue: 16, pages: 11536-11554

Type: Journal article (Peer reviewed)

Status: Published | Year: 2023 | DOI: https://doi.org/10.1021/acs.jmedchem.3c01059