“Chirality in Dynamic Combinatorial Chemistry.”
Dr G. Dan Pantos
University of Bath, U.K.
The first Dynamic Combinatorial approach to generate structural divergence from racemic building blocks. The divergence is due to a combination of a kinetic resolution during the synthesis of diastereomeric macrocycles and a stereospecific electron-donor (D) – electron-acceptor (A) interaction, leading to structurally distinct pseudorotaxanes.
These factors, combined with a difference in the stability of the final products, lead to the spontaneous assembly of two structurally different, non-isomeric [2]catenanes: one with a DAAD aromatic stack, while the other has a DADD stack.
Dan is working in the areas of supramolecular chemistry and organic materials.