Luca Laraia

Luca Laraia

Adjunkt

DTU KEMI
Institut for Kemi

Kemi: Faculty
Organisk Kemi: Jens Ø Duus
Organisk og Uorganisk Kemi Scientific Staff

Danmarks Tekniske Universitet

Kemitorvet

Bygning 207, rum 124

2800 Kgs. Lyngby

Hjemmeside

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Publikationer
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2018
 

Bioactive Compound Collections: From Design to Target Identification

Laraia, Luca ; Robke, Lucas ; Waldmann, Herbert
in: Chemical Engineering Progress, vol: 4, issue: 4, pages: 705-730

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1016/j.chempr.2018.01.012

 

Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors

Robke, Lucas ; Rodrigues, Tiago ; Schröder, Peter ; Foley, Daniel J. ; Bernardes, Gonçalo J.L. ; Laraia, Luca ; Waldmann, Herbert
in: Tetrahedron, vol: 74, pages: 4531-4537

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1016/j.tet.2018.07.021

 

EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology

Brennecke, Philip ; Rasina, Dace ; Aubi, Oscar ; Herzog, Katja ; Lanskron, Johannes ; Cautain, Bastien ; Vicente, Francisca ; Quintana, Jordi ; Stechmann, Bahne ; Brea, Jose ; Kolanowski, Jacek ; Pilarski, Radoslaw ; Orzaez, Mar ; Pienda-Lucena, Antonio ; Laraia, Luca ; Nami, Faranak ; Zielenkiewicz, Piotr ; Paruch, Kamil ; Hansen, Espen ; von Kries, Jens ; Neuenschwander, Martin ; Specker, Edgar ; Bartunek, Petr ; Simova, Sarka ; Lesinikowski, Zbigniew ; Krauss, Stefan ; Lëhtio, Lari ; Bilitewski, Ursula ; Broenstrup, Mark ; Tásken, Kjetil ; Lickert, Heiko ; Clausen, Mads Hartvig ; Andersen, Jeanette ; Vicent, Maria ; Genilloud, Olga ; Martinez, Aurora ; Nazaré, Marc ; Gribbon, Philip ; Fecke, Wolfgang
in: SLAS DISCOVERY: Advancing Life Sciences R&D

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    År: 2018     |    DOI: https://doi.org/10.1177/2472555218816276

2017
 

Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors

Laraia, Luca ; Ohsawa, Kosuke ; Konstantinidis, Georgios ; Robke, Lucas ; Wu, Yao-Wen ; Kumar, Kamal ; Waldmann, Herbert
in: Angewandte Chemie, vol: 129, issue: 8, pages: 2177–2182

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1002/ange.201611670

 

Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors

Xu, Hao ; Laraia, Luca ; Schneider, Laura ; Louven, Kathrin ; Strohmann, Carsten ; Antonchick, Andrey P. ; Waldmann, Herbert
in: Angewandte Chemie-international Edition, vol: 56, issue: 37, pages: 11232-11236

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1002/anie.201706005

 

Natural product inspired compound collections: evolutionary principle, chemical synthesis, phenotypic screening, and target identification

Laraia, Luca ; Waldmann, Herbert
in: Drug Discovery Today: Technologies, vol: 23, pages: 75-82

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1016/j.ddtec.2017.03.003

 

New Prodigiosin Derivatives Obtained by Mutasynthesis in Pseudomonas putida

Klein, Andreas S. ; Domrose, Andreas ; Bongen, Patrick ; Brass, Hannah U. C. ; Classen, Thomas ; Loeschcke, Anita ; Drepper, Thomas ; Laraia, Luca ; Sievers, Sonja ; Jaeger, Karl-Erich ; Pietruszka, Joerg
in: A C S Synthetic Biology, vol: 6, issue: 9, pages: 1757-1765

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1021/acssynbio.7b00099

 

Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34

Robke, Lucas ; Laraia, Luca ; Corrales, Marjorie A. Carnero ; Konstantinidis, Georgios ; Muroi, Makoto ; Richters, Andre ; Winzker, Michael ; Engbring, Tobias ; Tomassi, Stefano ; Watanabe, Nobumoto ; Osada, Hiroyuki ; Rauh, Daniel ; Waldmann, Herbert ; Wu, Yao-Wen ; Engel, Julian
in: Angewandte Chemie-international Edition, vol: 56, issue: 28, pages: 8153-8157

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1002/anie.201703738

2015
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Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

Laraia, Luca ; McKenzie, Grahame ; Spring, David R. ; Venkitaraman, Ashok R. ; Huggins, David J.
in: Cell Chemical Biology, vol: 22, issue: 6, pages: 689-703

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: https://doi.org/10.1016/j.chembiol.2015.04.019

 

Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction

Alza, Esther ; Laraia, Luca ; Ibbeson, Brett M. ; Collins, Suil ; Galloway, Warren R. J. D. ; Stokes, Jamie E. ; Venkitaraman, Ashok R. ; Spring, David R.
in: Chemical Science, vol: 6, issue: 1, pages: 390-396

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: https://doi.org/10.1039/C4SC02547D


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24 JANUAR 2019