Luca Laraia

Luca Laraia

Adjunkt

DTU KEMI
Institut for Kemi

Organisk Kemi: Jens Ø Duus
Organisk og Uorganisk Kemi Scientific Staff

Danmarks Tekniske Universitet

Kemitorvet

Bygning 207, rum 124

2800 Kgs. Lyngby

Hjemmeside

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Publikationer
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2018
 

Bioactive Compound Collections: From Design to Target Identification

Laraia, Luca ; Robke, Lucas ; Waldmann, Herbert
in: Chemical Engineering Progress (ISSN: 0360-7275), vol: 4, issue: 4, pages: 705-730, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: http://dx.doi.org/10.1016/j.chempr.2018.01.012

 

Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors

Robke, Lucas ; Rodrigues, Tiago ; Schröder, Peter ; Foley, Daniel J. ; Bernardes, Gonçalo J.L. ; Laraia, Luca ; Waldmann, Herbert
in: Tetrahedron (ISSN: 0040-4020), vol: 74, pages: 4531-4537, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: http://dx.doi.org/10.1016/j.tet.2018.07.021

2017
 

New Prodigiosin Derivatives Obtained by Mutasynthesis in Pseudomonas putida

Klein, Andreas S. ; Domrose, Andreas ; Bongen, Patrick ; Brass, Hannah U. C. ; Classen, Thomas ; Loeschcke, Anita ; Drepper, Thomas ; Laraia, Luca ; Sievers, Sonja ; Jaeger, Karl-Erich ; Pietruszka, Joerg
in: A C S Synthetic Biology (ISSN: 2161-5063), vol: 6, issue: 9, pages: 1757-1765, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: http://dx.doi.org/10.1021/acssynbio.7b00099

 

Natural product inspired compound collections: evolutionary principle, chemical synthesis, phenotypic screening, and target identification

Laraia, Luca ; Waldmann, Herbert
in: Drug Discovery Today: Technologies (ISSN: 1740-6749), vol: 23, pages: 75-82, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: http://dx.doi.org/10.1016/j.ddtec.2017.03.003

 

Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34

Robke, Lucas ; Laraia, Luca ; Corrales, Marjorie A. Carnero ; Konstantinidis, Georgios ; Muroi, Makoto ; Richters, Andre ; Winzker, Michael ; Engbring, Tobias ; Tomassi, Stefano ; Watanabe, Nobumoto ; Osada, Hiroyuki ; Rauh, Daniel ; Waldmann, Herbert ; Wu, Yao-Wen ; Engel, Julian
in: Angewandte Chemie-international Edition (ISSN: 1433-7851), vol: 56, issue: 28, pages: 8153-8157, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: http://dx.doi.org/10.1002/anie.201703738

 

Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors

Xu, Hao ; Laraia, Luca ; Schneider, Laura ; Louven, Kathrin ; Strohmann, Carsten ; Antonchick, Andrey P. ; Waldmann, Herbert
in: Angewandte Chemie-international Edition (ISSN: 1433-7851), vol: 56, issue: 37, pages: 11232-11236, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: http://dx.doi.org/10.1002/anie.201706005

 

Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors

Laraia, Luca ; Ohsawa, Kosuke ; Konstantinidis, Georgios ; Robke, Lucas ; Wu, Yao-Wen ; Kumar, Kamal ; Waldmann, Herbert
in: Angewandte Chemie (ISSN: 0044-8249), vol: 129, issue: 8, pages: 2177–2182, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: http://dx.doi.org/10.1002/ange.201611670

2015
 

Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction

Alza, Esther ; Laraia, Luca ; Ibbeson, Brett M. ; Collins, Suil ; Galloway, Warren R. J. D. ; Stokes, Jamie E. ; Venkitaraman, Ashok R. ; Spring, David R.
in: Chemical Science (ISSN: 2041-6520), vol: 6, issue: 1, pages: 390-396, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: http://dx.doi.org/10.1039/C4SC02547D

  PDF

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

Laraia, Luca ; McKenzie, Grahame ; Spring, David R. ; Venkitaraman, Ashok R. ; Huggins, David J.
in: Cell Chemical Biology (ISSN: 2451-9456), vol: 22, issue: 6, pages: 689-703, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: http://dx.doi.org/10.1016/j.chembiol.2015.04.019

2014
 

Diversity-Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems

Galloway, Warren R. J. D. ; Wilcke, David ; Nie, Feilin ; Hadje-Georgiou, Kathy ; Laraia, Luca ; Spring, David R.
part of: Concepts and Case Studies in Chemical Biology (ISBN: 9783527336111), pages: 379-389, 2014, Wiley-VCH,

Type: Book chapter (Peer reviewed)

Status: Published     |    År: 2014     |    DOI: http://dx.doi.org/10.1002/9783527687503.ch26


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24 SEPTEMBER 2018