PhD scholarship in Medicinal Chemistry

tirsdag 18 maj 21

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Frist 18. juni 2021
Du kan søge om jobbet ved DTU Kemi ved at udfylde den efterfølgende ansøgningsformular.

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A PhD scholarship in Medicinal Chemistry is available at DTU Chemistry. You will work with fragment-based drug discovery (FBDD) as part of a collaboration between DTU, the University of Copenhagen and the University of Miami. The project is funded by Independent Research Fund Denmark. You will join a team looking to develop small molecules with potential for studying and treating inflammatory disorders, such as neurodegenerative disease.

Responsibilities and qualifications
You will be responsible for screening our in-house fragment collection against protein targets and performing follow-up secondary screening using biophysical methods. You will also be in charge of hit-to-lead medicinal chemistry in collaboration with experts in structural biology. As part of the team focused on screening and FBDD, you are furthermore expected to teach undergraduate courses and to supervise undergraduate research projects. During the project you will be expected to learn the basics of cell biology and to work with cultured mammalian cells at DTU and the University of Miami.

You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree. Ideally, your degree should be in medicinal chemistry, but applicants with a degree in synthetic chemistry or pharmacy are also encouraged to apply.

More specifically you should ideally have the following qualifications:

  • Extensive experience with the design and execution of synthetic routes to small molecules
  • Characterization of small molecules by LCMS and spectroscopic techniques
  • Thorough knowledge of the properties that makes good probes and leads for drug discovery, including ADME/DMPK
  • Experience with the analysis of small molecule-protein interactions is an advantage
  • Experience in advanced NMR spectroscopy is an advantage
  • Experience with FBDD is an advantage

The language of communication at DTU is English.

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide.

Assessment
The assessment of the candidates will be made by Prof. Mads H. Clausen and Assoc. Prof. Charlotte Held Gotfredsen.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

Potential start date September 1st 2021 (or as soon as possible thereafter).

You can read more about career paths at DTU here.

Further information
Further information may be obtained from Prof. Mads H. Clausen, tel.: +45 4525 2131, mhc@kemi.dtu.dk.

You can read more about DTU Chemistry at www.kemi.dtu.dk and more about the research group at www.kemi.dtu.dk/mhc

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure
Your complete online application must be submitted no later than 18 June 2021 (Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • A letter motivating the application (cover letter)
  • Curriculum vitae, including any publications and contact information of at least two references
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)

You may apply prior to ob­tai­ning your master's degree but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,900 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.