PhD scholarship in Protein Chemistry and Structural Biology

DTU Kemi
fredag 27 jan 17

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Frist 24. februar 2017
Du kan søge om jobbet ved DTU Kemi ved at udfylde den efterfølgende ansøgningsformular.

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A 3-year PhD scholarship in Protein Chemistry, Structural and Computational Biology is available at Department of Chemistry, Technical University of Denmark. The position will be available from the 15th of March 2017 or as soon as possible thereafter.

The project focusses on elucidating the structural and dynamic basis for the allosteric regulation of tryptophan hydroxylase isoform 2 (TPH2). TPH2 is a brain-specific, multi-domain enzyme that catalyzes the first and rate-limiting step in the synthesis of the neurotransmitter serotonin. In order to achieve the objective, an interdisciplinary approach will be used that will combine in-silico modeling, with state-of-the-art experiments such as X-ray scattering, dynamic light scattering and Hydrogen/Deuterium exchange coupled to mass spectrometry to trace the allosteric cooperativity in TPH2. Bioinformatics tools will be used to dissect the allosteric site and to suggest mutant TPH2 variants that will be expressed, purified and biophysically characterized in order to identify amino acid residues important for ligand binding. The results will shed light on the molecular mechanism of the allosteric regulation of TPH2 and will provide new avenues to modulate enzyme activity through binding of selective drugs to the allosteric site.

Qualifications
Candidates should have a master's degree in engineering or a similar degree with an academic level equivalent to the master's degree in engineering.   

Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.    

Assessment
The assessment of the applicants will be made by Associate Professors Günther H. Peters, Hans E.M. Christensen and Pernille Harris.   

We offer
We offer an interesting and challenging job in an international environment focusing on education, research, scientific advice and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world. 

Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.   

Further information
Further information may be obtained from Associate Professors Günther H. Peters, mail: ghp@kemi.dtu.dk.    

You can read more about DTU Chemistry on www.kemi.dtu.dk/english.   

Application
Please submit your online application no later than 24 February 2017. Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one pdf file. The file must include: 

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here)

Candidates may apply prior to ob­tai­ning their master's degree, but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.    

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,600 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.