Metalloenzymes and Neuropsychiatric Disorders

This project concerns production and characterization of iron- and copper-containing mono­oxygenases involved in neuropsychiatric disorders. An example is the iron-containing enzyme tryptophan hydroxylase, which catalyzes the rate-limiting step in the biosynthesis of the neurotransmitter serotonin. Bacterial strains for expression of different variants of this enzyme have been developed. This allows us to study the structural and functional properties of tryptophan hydroxylase, which gives valuable information for the development of new medicine in the treatment of neuropsychiatric disorders connected with imbalance in the brain serotonin level.

If you have any questions or comments on this research programme please contact Hans E. Mølager Christensen, hemc@kemi.dtu.dk